Stem Cells & Exosomes Specialist

Ann Long, MD Our Services Stem Cells & Exosomes

Ann Long, MD

Aesthetics & Anti Aging Medicine located in Lower Manhattan, New York, NY

Stem Cells & Exosomes Q & A

What are the umbilical cord stem cells? Are they safe?

According to the FDA’s and AABB’s donor eligibility guidelines, the umbilical cord blood was collected from a health, disease free woman (by medical history, social history and blood test) donor at the time of her delivery. The cells are processed using a proprietary method. It is sent to an independent 3rd party CLIA Lab for sterility testing and has passed the regulatory requirements. 

 

How do the stem cells actually work?

 

When umbilical cord stem cells are placed into an environment of injured tissue, the stem cells go to work inhibiting the damaging inflammatory components and modulating the immune system.  At the same time, the monocleated cells produce growth factors that increase vasculature and nourish damaged cells back to health and stimulate our own cells to regenerate themselves.

How many types of stem cells are available? Why do we choose umbilical cord blood stem cells?

 

Live nucleated cells from umbilical cord blood are young, vibrant cells that have not been affected by age or disease.  Whereas bone marrow aspirate and adipose-derived stem cells are significantly older and potentially damaged by disease.

 

How soon after the injection can I expect to have some improvement?

For the joint injection, some people will experience pain relief within hours or a few days depend on the present state of the patient’s joint.

 

What activity level can I have after the injection?

NOT increase your activity level above your pre-injection activity level.  Give the cells 3 weeks to aid in repair PRIOR to starting an exercise regimen that should be slowly progressing to pre-injection states.

 

  1. NO NSAIDS/Biologic 3 days prior or 3 months after the injection.

 

  1. Contra-indications:

 

(1) Absolute contra-indications

 

  • Post organ transplant or on the transplant list
  • Immune-compromised (as HIV)
  • Those with active Flu-like syndromes.
  • Pregnant, or those that are trying to become pregnant

(2) Relative Contra-indications

  • Active cancer or cancer within the last 5 years
  • Significant food and/or drug allergies
  • Known allergy to Sulfa (Cryopreservant)
  • Children under 12 years old

 

  1. Potential Adverse Reaction:

 

  1. Common Adverse Reaction

 

  • Inflammatory
  • Pain (mostly seen to those recently have joint surgery, joint infection or systemic infection)

(2) Uncommon Adverse Reactions:

  • Nausea
  • Fever
  • Chill

(3) Allergic reaction to DMSO (if H1/H2 inhibitor was not used during patient prep)

 

什么是脐带血干细胞？安全吗？

根据美国FDA 和 AABB合适供体条例，仔细调查供体的病史，家族史及生活习俗，通过严格的身体和血液检查，选择健康，无疾病的自愿孕妇在其分娩时，按标准程序收集处理这些健康，新鲜的脐带血，经过独立的第三检验室测验，通过无菌试验及符合所有的条件才可使用。

干细胞是怎样真正起作用？

当把脐带血干细胞输入受伤的组织中，干细胞通过抑制组织损伤后产生的炎症成份和调节其免疫系统，同时其单核细胞产生生长因子，增加新生血管的产生，营养受损的细胞，使其恢复到健康状态，刺激自身细胞再生而达到修复和治疗的目的。

有多少种干细胞可以选用，为什么要选择脐带血干细胞？

从脐带血所提取的干细胞是最年轻，最有活力的活有核细胞，从未受过年龄老化和疾病的影响。而从我们自身骨髓或脂肪组织提取的干细胞会明显受年龄老化和疾病损伤影响其质量和效果。

注射后多久看到改善？

对关节注射而言，决定于当时的关节状态，有的在注射后几小时至几天内可感到关节疼痛减轻。

注射后可运动吗？

注射后关节的活动状态不能高于注射前，需要3周慢慢逐渐恢复到注射前运动水平。

药物使用禁忌？

注射前3天至注射后3个月，要停用所有的止痛药，NSAIDS和免疫抑制剂。

干细胞治疗禁忌？

  1. 绝对禁忌：

器官移植后或正在等待器官移植者

                     免疫缺陷者：如艾滋病

                    正在感冒症状者

                   怀孕或正准备怀孕者

  1. 相对紧忌：

患有癌症或癌症在5年内

                      明显食物或药物过敏者

                     对磺胺类过敏

                    12岁以下的儿童

有 哪些不良反应？

（1）常见的不良反应：炎症反应，疼痛，大部分见于近期关节手术，关节或全身感染者。

（2）少见的不良反应：恶心，发烧，寒颤。

（3）对DMSO过敏反应（如果不预先用H1和 H2阻断剂）

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